3/12/2024 0 Comments Mercury poisoning song![]() The absorption of elemental is insignificant on oral ingestion. The elemental mercury can be volatile at room temperatures, and the volatility increases with the rise in temperatures and aerosolization. The vaporized form of elemental mercury is more readily absorbed as compared to the oral or intravenous route. The toxic effects of mercury depend on the form of mercury, age of the individual, route of exposure, biotransformation, accumulation in the target organs, and comorbidities. ![]() The neural degeneration associated with mercury poisoning is responsible for the painful extremities, peripheral neuropathy, and associated neuropsychiatric symptoms, as seen in acrodynia. The inactivation of catecholamine-0-methyl transferase can explain arterial hypertension associated with mercury, which in turn increases serum and urinary epinephrine, norepinephrine, and dopamine. The mechanism of acrodynia may also involve adrenocortical hyperfunction, sympathetic vasomotor dysfunction, and catecholamine dysfunction. There can be genetic variation in the idiosyncratic sensitivity of individuals due to the toxic effects of mercury. The involvement of the immune system in the form of delayed hypersensitivity has been proposed in the causation of acrodynia. Mercury absorption can manifest in varied forms due to its vast systemic involvement. The interaction of mercury with many intracellular moieties results in the dysfunction of enzymes, membrane transportation, and structural proteins. Locally, mercury can produce corrosive actions due to its oxidizing and corrosive action. Mercury, in its various forms, has an affinity for the ubiquitous sulfhydryl groups in the tissues by forming covalent bonds. Certain traditional ayurvedic medicines contain a significant amount of mercury and have caused cases of acrodynia. Mercury-containing preservatives (thiomersal), calomel containing diaper powders, plant fungicides, anthelmintics, mercury ointments, certain bactericidal agents, alternate, medicine drugs, folk medicines, and interior latex paints pose a hazard of causing mercury toxicity in domestic settings. In the present, only rare cases of acrodynia with varied presentations are reported in the literature, most of which are related to accidental exposure to mercury in non-occupational settings. Between 19, the official death record from acrodynia was 585 in England, which dropped to 57 in 1957 and seven in 1955. The earlier research resulted in the withdrawal of mercury-containing tooth powders from the market and hence the decreased morbidity and mortality. The incidences were more common in infants and children less than two years, highest among the age group of nine-month-old. ![]() It was present in every one in 500 children exposed to the mercury present in the dental amalgams. The condition was prevalent in the first half of the 20 century in Europe, America, and Australia. Newborn babies and adults are less vulnerable. The disease is mostly seen in infants and young children. There is no exact data regarding the present prevalence of acrodynia.
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